July 2014 News

Dr. John KaranicolasJohn Karanicolas (assistant professor) is the recipient of an award from the J.R. and Inez Jay Fund for his project entitled "Identifying stabilizers of p53 using pocket complimentarity." This award will allow his team to search for compounds that restore cellular activity to mutant forms of the p53 tumor suppressor: such compounds may serve as a starting point for development of new anti-cancer drugs. This is a collaborative project involving Mark Fisher (KUMC Biochemistry and Molecular Biology), Tomoo Iwakuma (KUMC Cancer Biology), Scott Lovell (KU Protein Structure Lab), and Steven Rogers (KU Med Chem Lab).

 

Im Biophysical Journal CoverDr. Wonpil Im (associate professor) has his research highlighted on the cover of Biophysical Journal, for his article entitled “E. coli outer membrane and interactions with OmpLA.”

 



 

Dr. Liang XuLiang Xu (associate professor) is the recipient of a Pilot Project Award from the Center for Biomedical Research Excellence in Protein Structure and Function for his project entitled “Fragment based drug discovery for inhibitors of RNA-Binding HuhR.”  The major goal of this proposal is the find lead compounds that will be a starting point for breast cancer therapeutics.

 

 

Dr. Del ShankelDelbert Shankel (Professor Emeritus of Microbiology and former Chancellor of the University) has provided an invited perspective on the life of Professor Charlotte Auerbach for Mutation Research/ Reviews in Mutations Research.  Professor Auerbach is credited with the discovery that chemicals are mutagenic and with pioneering studies of mutations in animals; these were observations made during World War II and many were allowed to be published only after the war.  Dr. Shankel spent a sabbatical year in 1967 with Professor Auerbach, and the article is entitled "Memories of a Friend and Mentor – Charlotte Auerbach".

 

James Akagi (Retired Professor) visited KU in early June, traveling from his current home in the Seattle area.  He spent the day reminiscing about his days in the former Department of Microbiology, catching up with friends and colleagues, meeting new Molecular Biosciences Faculty Members and learning about current research and other developments in the department.  Jim is shown here (center) with faculty members Scott Hefty, Dean Stetler, Susan Egan and Steve Benedict outside the new Akagi Conference Room in the Molecular Biosciences office.  

 

Michael Barta (postdoctoral fellow, Hefty lab) won an iPad mini for his best poster entitled “Structural and Genetic Evidence Support that Chlamydia trachomatis CT398 (CdsZ) Interacts with σ54 (RpoN) and the Type III Secretion Export System” at the Second Annual Symposium on Structural Biology sponsored by the Oklahoma Center for Biomedical Research Excellence in Structural Biology at the University of Oklahoma on June 9.  Michael is pictured with Ann West, director of the COBRE and Joseph A. Brandt Professor of Chemistry and Biochemistry.

 

 

 

Kara Hinshaw (graduate student, Chandler lab) will be appointed to the National Institutes of Health funded Graduate Training Program in Dynamic Aspects of Chemical Biology Training Grant on July 1 for a term of two years.

 

 

 

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July 2014 Presentations

Brian Ackley (associate professor) gave a lecture at the 7th International Adhesion GPCR Workshop entitled “The C. elegans Celsr ortholog, FMI-1, regulates axon guidance and synaptogenesis via distinct mechanisms.”  The workshop was held at The Children’s Hospital in Boston, MA on June 6th.

Dr. Wonpil Im (associate professor) gave a lecture in the Centre Européen de Calcul Atomique et Moléculaire Workshop in Dublin, Ireland entitled “Membrane Protein Simulation: One Step Closer to Users” on June 4.   He also gave a lecture entitled “Biomolecular Modeling and Simulation using CHARMM-GUI” at the 2nd Molecular Simulation Summer School in Calgary, Canada on June 24.

Dr. Erik Lundquist (Professor) presented a talk entitled “Using the model organism nematode worm C. elegans to understand neuronal development” at the NIH, NIGMS Fifth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE)  in Washington D.C. on June 18th.

More Presentations

July 2014 Publications

Sundararajan L, Norris ML, Schoneich S, Ackley BD, Lundquist EAThe fat-like cadherin CDH-4 acts cell non-autonomously in anterior-posterior neuroblast migration.  Dev Biol.  [Epub ahead of print]

Zeineldin M, Jensen D, Paranjape SR, Parelkar NK, Jokar I, Vielhauer GA, Neufeld KL. Human Cancer Xenografts in Outbred Nude Mice Can Be Confounded by Polymorphisms in a Modifier of Tumorigenesis  Genetics. [Epub ahead of print]

Zeineldin M, Miller MA, Sullivan R, Neufeld KL. Nuclear Adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice  Carcinogenesis [Epub ahead of print]

 More Publications


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Kathy Meneely (postdoctoral fellow, Lamb lab) presented a poster entitled “Structure informs on function: A thiazolinyl imine reductase of siderophore biosynthesis” at the Second Annual Symposium on Structural Biology sponsored by the Oklahoma Center for Biomedical Research Excellence in Structural Biology at the University of Oklahoma on June 9. http://structuralbiology.ou.edu/symposium
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