Programs - Biochemistry

This program emphasizes a focus on the study of structural and functional aspects of specific biomolecules rather than of cells or whole organisms. Faculty in this program offer training in a wide variety of modern biochemical and biophysical techniques, including: X-ray crystallography, NMR, fluorescence spectroscopies, mass spectrometry, confocal microscopy, computational chemistry, protein chemistry, molecular biology, and genetics.

The role of posttranslational modification by SUMO on cell division cycle
Dr. Yoshiaki Azuma

Role of localized mRNA in Drosophila gene regulation and development
Dr. Robert Cohen

Molecular virology and pathogenesis of herpes simplex virus
Dr. David Davido

NMR of molecular interactions in pathogenesis
Dr. Roberto de Guzman

Transcription regulation, Development of novel anti-bacterial agents
Dr. Susan Egan

Role of tau in Alzheimer's and other neurodegenerative disorders
Dr. Chris Gamblin

Role of ribozymes and enzymes in tRNA processing
Dr. Peter Gegenheimer

Protein and membrane transport in the late secretory pathway
Dr. Edina Harsay

Mechanisms of developmental gene regulation and pathogenesis for Chlamydia
Dr. P. Scott Hefty

Theoretical/computational methods to chemical and physical problems in biology and material science
Dr. Wonpil Im

Unraveling cytokine signaling complexity using computational and experimental protein design techniques
Dr. John Karanicolas

Modeling of protein structure, dynamics and interactions
Dr. Krzysztof Kuczera

Structural and functional analysis of enzymes associated with iron uptake
Dr. Audrey Lamb

Redundancy in the genome and genetic mechanisms of organismal morphogenesis
Dr. Erik Lundquist

The role of the APC protein in the suppression of colon cancer
Dr. Kristi Neufeld

We are using molecular genetic approaches to stimulate production of novel secondary metabolites
Berl R. Oakley

Molecular mechanism of invasion of human tissues by pathogenic microorganism
Dr. William Picking

Structure and dynamics of the ATP synthase and other molecular machines
Dr. Mark Richter

Autoimmunity; Development of specific therapeutic reagents for treatment of systemic lupus erythematosus (SLE)
Dr. Dean Stetler

Structure and function of key biomacromolecules
Dr. Fusao Takusagawa

The structural basis of assembly, dynamics and function of molecular complexes from viruses and bacterial injectosome by using X-ray crystallography and electron cryo-microscopy
Dr. Liang Tang

Molecular modeling in the context of structural genomics and bioinformatics
Dr. Ilya Vakser

Molecular switches in viral replication
Dr. Robert Weaver

Developing various novel computational algorithms to generate large-scale, high-throughput predictions of tertiary protein structures and protein-protein interactions from amino acid sequences
Dr. Yang Zhang